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KMID : 0895419940040020148
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Journal of Korean Society of Occupational and Enviromental Hygiene
1994 Volume.4 No. 2 p.148 ~ p.156
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Studies on Hepatic Microsomal Alcohol Dehydrogenase < ADH > and Aldehyde Dehydrogenase < ALDH > Activities in Rats Treated with Trichloroethylene
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양정선/Yang, Jeong Sun
김기웅/박인정/강선규/문영한/Kim, Ki Woong/Park, In Jeong/Kang, Seong Kyu/Moon, Young Hahn
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Abstract
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Chloral hydrate(CH), an intermediate metabolite of trichloroethylene(TRI) is reduced to trichloroethanol(TCE-OH), and is oxidized to trichloroacetic acid(TCA) by the nicotinamide adenine dinucleotide(NAD)-dependent enzymes such as alcohol dehydrogenase(ADH} and aldehyde dehydrogenase(ALDH) in liver.
This study was performed to find out the change of activity of ADH and ALDH with increasing amount of TRI. Intraperitoneal injection of TRI were done to the male Sprague Dawely rats(mean body weight, 170 10g) in corn oil at the dosage of 150, 300, 600 ㎎/㎏ for 2 days. The results of experiments are following :
1. The contents of xenobiotic metabolic enzymes in liver are tended to be decreased with increasing amount of, but not significantly (P$gt;0.05).
2. Activity of ADH in microsome is decreased (p$lt;0.05), and activity of ALDH is increased with amount of TRI (P$lt;0.05).
3. Total trichloro-compounds(TTC) concentration in urine are increased with amount of TRI, but the ratio of between the TCE-OH and the TCA were not shown any critical change.
These results suggests that the ALDH in microsome may be related to metabolism of TRI, but ADH was nothing less than the effected to metabolism of TRI.
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KEYWORD
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